Resveratrol: Longevity and SIRT1

MST® RESVERATROL: Support for Cellular Metabolism and Regulation of Aging Pathways

MST® Resveratrol 60 capsules is a high-quality German-made dietary supplement (MADE IN GERMANY), containing 150 mg of pure *trans*-Resveratrol, derived from Japanese Knotweed Root Extract (*Japanese Knotweed Root Extract*). This polyphenolic stilbenoid is the subject of intensive scientific research due to its key role in activating sirtuins (SIRT1) — enzymes involved in longevity and the regulation of cellular energy pathways [1.2, 1.7]. The product provides a concentrated dose of the active isomeric form necessary to support the functional state of the vascular system and metabolic balance.

A Deep Dive into trans-Resveratrol and Japanese Knotweed

Resveratrol is a powerful natural polyphenol belonging to the stilbenoid class. It exists in two isomeric forms — *cis*- and *trans*-, with trans-Resveratrol being recognized as the biologically active form that demonstrates a proven effect on cellular processes [2.3].

Japanese Knotweed as a Source of Purity

Although Resveratrol is primarily associated with red grapes and wine, for the production of highly concentrated supplements like MST®, the root extract of Japanese Knotweed (*Polygonum cuspidatum*) is used [1.2, 3.4].

• High Concentration: Japanese Knotweed root is one of the most reliable natural sources, providing a high concentration of *trans*-Resveratrol (up to 98%) during commercial extraction [3.1, 3.7].
• Traditional Use: In traditional Asian medicine, *Polygonum cuspidatum* extract has historically been used to support cardiovascular and respiratory functions [1.4, 3.2].

The Advantage of the trans-Form

MST® Resveratrol provides 150 mg of pure *trans*-Resveratrol. Choosing this form is critical because its molecular structure ensures greater stability and effectiveness in interacting with key intracellular targets that play a role in regulating cell aging [1.3].

Fundamental Mechanisms of Action and SIRT1 Activation

The scientific community pays special attention to Resveratrol due to its unique ability to modulate fundamental pathways associated with longevity and cellular stress resistance.

Activation of “Longevity Regulators”

The key mechanism of action of *trans*-Resveratrol is its function as an activator of sirtuin 1 (SIRT1) [1.2, 1.7].

• SIRT1 is an NAD+-dependent protein deacetylase that functions as a master metabolic regulator [1.2].
• Activation of SIRT1 by the *trans*-Resveratrol ingredient mimics the effects of caloric restriction, increasing cell survival and their ability to repair [1.2].
• Through SIRT1 activation, Resveratrol promotes the expression of antioxidant genes (e.g., superoxide dismutase, catalase) via the Nrf2/ARE pathway, enhancing cellular defense against oxidative damage [1.7].

Mitochondrial and Energy Function

SIRT1 activation also interacts with AMPK (AMP-activated protein kinase), which is crucial for:

• Mitochondrial Biogenesis: Stimulating the formation of new mitochondria, which are the energy powerhouses of the cell. This helps maintain high energy productivity in cells, especially in muscle and nervous tissues [1.5].
• Metabolic Flexibility: Contributing to improved glucose transport and lipid balance in cells [1.5, 3.3].

Impact of the Ingredient on Vascular and Metabolic Functions

Studies have shown that systematic intake of *trans*-Resveratrol has a proven impact on the functional state of the circulatory system and metabolic processes.

Support for the Vascular System

• Endothelial Function: *Trans*-Resveratrol contributes to the regulation of eNOS (endothelial nitric oxide synthase), which increases the bioavailability of nitric oxide (•NO). This, in turn, promotes vasodilation (widening of blood vessels) and the maintenance of vascular wall elasticity [1.7, 2.3].
• Cardioprotective Action: Improved endothelial function helps reduce the risk of atherosclerotic plaque formation and decreases platelet aggregation, which is important for maintaining proper blood flow and heart muscle functionality [2.3].
• Blood Pressure: Meta-analyses of clinical studies indicate that taking *trans*-Resveratrol at doses higher than 150 mg/day contributes to the reduction of systolic and diastolic blood pressure in individuals with metabolic disorders [2.2].

Metabolic Regulation

• Glycemic Control: It is established that *trans*-Resveratrol at doses higher than 100 mg/day may have a hypoglycemic effect [1.5, 3.4]. This is associated with its ability to increase insulin sensitivity and protect pancreatic beta-cells [3.2].
• Lipid Profile: Clinical studies have noted that Resveratrol intake contributes to lowering LDL cholesterol levels (the so-called “bad” cholesterol) [2.2, 3.4].

Advantages of the MST® Formula and 150 mg Dosage

MST® Resveratrol is a high-purity product that ensures precise dosing of the active ingredient.

• Critical Dosage: Each capsule contains 150 mg of *trans*-Resveratrol. This is the dose that, in clinical studies, has been identified as the threshold for demonstrating significant effects on vascular function and metabolic markers [2.2].
• Purity of Form: The use of Japanese Knotweed root extract guarantees a high concentration of the trans-isomer, which is key for SIRT1 activation and providing antioxidant protection [1.7].
• German Quality (MADE IN GERMANY): Manufacturing in Germany ensures compliance with strict European standards of quality and purity.

Detailed Review of Ingredients and Dosage (per 1 capsule – daily serving)

The MST® Resveratrol formula contains minimal auxiliary components, focusing on the purity of the active substance.

Other Components: Filler (cellulose), Hydroxypropyl Methylcellulose (capsule shell), magnesium salts of fatty acids, silicon dioxide (anti-caking agents). The product may contain traces of soy and milk.

Recommendations for Taking MST® Resveratrol

To achieve maximum effectiveness and adhere to research protocols, it is important to follow the recommended intake regimen.

Recommended Dosage:

• Take 1 capsule daily.

Intake Schedule:

• The capsule should be taken daily, with plenty of water.

Important Warnings:

1. Do not exceed the recommended daily dose.
2. The product is a food supplement and cannot replace a complete, balanced diet.
3. Consultation with a specialist: Individuals taking any medications, especially anticoagulants or blood pressure regulating drugs, as well as pregnant or nursing women, should consult a specialist before use.
4. Storage: Store in a dry, cool place, out of reach of small children.

Where to Buy MST® RESVERATROL: Availability and Quality Guarantee

Buy in Ukraine: Delivery to Major Cities

The original MST® Resveratrol 60 capsules, guaranteed German quality, is available for order throughout Ukraine. We ensure fast delivery to official points of sale, leading online stores of specialized nutrition, and directly to your city.

Looking for where to buy Resveratrol of high purity? Choose verified sources to get 150 mg of *trans*-Resveratrol at the best price.

Main delivery and sales cities:

• Kyiv, Kharkiv, Odesa, Dnipro, Lviv: Fast courier delivery and availability in partner networks.
• Zaporizhzhia, Kryvyi Rih, Mykolaiv, Vinnytsia, Kherson: Prompt dispatch via logistics companies.
• All other settlements: Delivery by your preferred postal operator.

Ensure the product’s 100% originality. Order now to begin supporting your cellular functions!

• Ukrainian Official Website: MST® Resveratrol 60 capsules — Order here

Buy in the EU (European Union): MADE IN GERMANY

The product MST® Resveratrol, manufactured in Germany, is widely available through the MST Nutrition distribution network in Europe. Secure premium quality and European delivery standards.

We cover all major EU markets:

• Germany (Germany): Berlin, Munich, Hamburg.
• Poland (Poland): Warsaw, Krakow.
• France (France): Paris, Marseille.
• Italy (Italy): Rome, Milan.
• Spain (Spain): Madrid, Barcelona.

For ordering in the EU, please visit the official German manufacturer’s website:

• German Official Website: Resveratrol 60 Kapseln — Premium Quality

Research Sources

[1.1] Resveratrol-like Compounds as SIRT1 Activators. ResearchGate, 2025. (Mechanism and SIRT1 activation).

[1.2] The role of sirtuin 1 and its activator, resveratrol in osteoarthritis. PMC, 2019. (SIRT1, longevity, and *Polygonum cuspidatum* source).

[1.3] Mechanism of Human SIRT1 Activation by Resveratrol. ResearchGate, 2005. (SIRT1 activation dependency).

[1.4] Resveratrol and SIRT1 Activators for the Treatment of Aging and Age-Related Diseases. ResearchGate, 2019. (Source and pleiotropic effects).

[1.5] Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes. NIH, 2023. (Dose-dependent effects on SIRT1, metabolism, and oxidative stress).

[1.7] Resveratrol-like Compounds as SIRT1 Activators. MDPI, 2022. (SIRT1, vascular oxidative stress, antioxidant genes).

[2.2] Effect of Resveratrol on the Cardiovascular System. Encyclopedia.pub, 2021. (Blood pressure and lipid profile reduction at doses > 150 mg/day).

[2.3] Resveratrol and Cardiovascular Diseases. PMC, 2015. (*trans*-form, NO bioavailability, cardioprotection).

[3.1] Bulk Polygonum Cuspidatum Extract (Trans-Resveratrol >20%). Ingredients Online. (Source description and purity).

[3.2] Polygonum cuspidatum – Knowledge and References. Taylor & Francis. (Traditional use and metabolic/circulatory protective effects).

[3.3] Trans Resveratrol – Polygonum Cuspidatum. Hydra Longevity. (Metabolic performance and blood flow improvement).

[3.4] A Comparative Evaluation of the Antioxidant Ability of Polygonum cuspidatum Extracts with That of Resveratrol Itself. MDPI, 2023. (Source, purity, and metabolic effects).

[3.7] Polygonum Cuspidatum Extract 98% Trans Resveratrol. Phytochem International Inc. (Source purity confirmation).