{"id":1001985,"date":"2025-11-17T21:17:23","date_gmt":"2025-11-17T19:17:23","guid":{"rendered":"https:\/\/mstnutrition.ua\/?p=1001985"},"modified":"2025-11-17T22:17:16","modified_gmt":"2025-11-17T20:17:16","slug":"resveratrol-dovgolittya-ta-sirt1","status":"publish","type":"post","link":"https:\/\/mstnutrition.ua\/en\/resveratrol-dovgolittya-ta-sirt1\/","title":{"rendered":"Resveratrol: Longevity and SIRT1"},"content":{"rendered":"<h2>MST\u00ae RESVERATROL: Support for Cellular Metabolism and Regulation of Aging Pathways<\/h2>\n<p>&nbsp;<\/p>\n<p>MST\u00ae Resveratrol 60 capsules is a high-quality German-made dietary supplement (<b>MADE IN GERMANY<\/b>), containing <b>150 mg of pure *trans*-Resveratrol<\/b>, derived from <b>Japanese Knotweed Root Extract<\/b> (*Japanese Knotweed Root Extract*). This polyphenolic stilbenoid is the subject of intensive scientific research due to its key role in activating <b>sirtuins (SIRT1)<\/b> \u2014 enzymes involved in longevity and the regulation of cellular energy pathways [1.2, 1.7]. The product provides a concentrated dose of the active isomeric form necessary to support the functional state of the vascular system and metabolic balance.<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h3>A Deep Dive into trans-Resveratrol and Japanese Knotweed<\/h3>\n<p>Resveratrol is a powerful natural polyphenol belonging to the stilbenoid class. It exists in two isomeric forms \u2014 *cis*- and *trans*-, with <b>trans-Resveratrol<\/b> being recognized as the biologically active form that demonstrates a proven effect on cellular processes [2.3].<\/p>\n<h4>Japanese Knotweed as a Source of Purity<\/h4>\n<p>Although Resveratrol is primarily associated with red grapes and wine, for the production of highly concentrated supplements like MST\u00ae, the root extract of <b>Japanese Knotweed (*Polygonum cuspidatum*)<\/b> is used [1.2, 3.4].<\/p>\n<ul>\n<li><b>High Concentration:<\/b> Japanese Knotweed root is one of the most reliable natural sources, providing a high concentration of *trans*-Resveratrol (up to 98%) during commercial extraction [3.1, 3.7].<\/li>\n<li><b>Traditional Use:<\/b> In traditional Asian medicine, *Polygonum cuspidatum* extract has historically been used to support cardiovascular and respiratory functions [1.4, 3.2].<\/li>\n<\/ul>\n<h4>The Advantage of the trans-Form<\/h4>\n<p>MST\u00ae Resveratrol provides 150 mg of pure *trans*-Resveratrol. Choosing this form is critical because its molecular structure ensures greater stability and effectiveness in interacting with key intracellular targets that play a role in regulating cell aging [1.3].<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h3>Fundamental Mechanisms of Action and SIRT1 Activation<\/h3>\n<p>The scientific community pays special attention to Resveratrol due to its unique ability to modulate fundamental pathways associated with longevity and cellular stress resistance.<\/p>\n<h4>Activation of &#8220;Longevity Regulators&#8221;<\/h4>\n<p>The key mechanism of action of *trans*-Resveratrol is its function as an <b>activator of sirtuin 1 (SIRT1)<\/b> [1.2, 1.7].<\/p>\n<ul>\n<li><b>SIRT1<\/b> is an NAD+-dependent protein deacetylase that functions as a master metabolic regulator [1.2].<\/li>\n<li>Activation of SIRT1 by the *trans*-Resveratrol ingredient <b>mimics the effects of caloric restriction<\/b>, increasing cell survival and their ability to repair [1.2].<\/li>\n<li>Through SIRT1 activation, Resveratrol promotes the expression of antioxidant genes (e.g., superoxide dismutase, catalase) via the Nrf2\/ARE pathway, enhancing cellular defense against oxidative damage [1.7].<\/li>\n<\/ul>\n<h4>Mitochondrial and Energy Function<\/h4>\n<p>SIRT1 activation also interacts with <b>AMPK<\/b> (AMP-activated protein kinase), which is crucial for:<\/p>\n<ul>\n<li><b>Mitochondrial Biogenesis:<\/b> Stimulating the formation of new mitochondria, which are the energy powerhouses of the cell. This helps maintain high energy productivity in cells, especially in muscle and nervous tissues [1.5].<\/li>\n<li><b>Metabolic Flexibility:<\/b> Contributing to improved glucose transport and lipid balance in cells [1.5, 3.3].<\/li>\n<\/ul>\n<hr \/>\n<p>&nbsp;<\/p>\n<h3>Impact of the Ingredient on Vascular and Metabolic Functions<\/h3>\n<p>Studies have shown that systematic intake of *trans*-Resveratrol has a proven impact on the functional state of the circulatory system and metabolic processes.<\/p>\n<h4>Support for the Vascular System<\/h4>\n<ul>\n<li><b>Endothelial Function:<\/b> *Trans*-Resveratrol contributes to the regulation of <b>eNOS<\/b> (endothelial nitric oxide synthase), which increases the bioavailability of nitric oxide (\u2022NO). This, in turn, promotes <b>vasodilation<\/b> (widening of blood vessels) and the maintenance of <b>vascular wall elasticity<\/b> [1.7, 2.3].<\/li>\n<li><b>Cardioprotective Action:<\/b> Improved endothelial function helps reduce the risk of atherosclerotic plaque formation and decreases platelet aggregation, which is important for maintaining proper blood flow and heart muscle functionality [2.3].<\/li>\n<li><b>Blood Pressure:<\/b> Meta-analyses of clinical studies indicate that taking *trans*-Resveratrol at doses higher than 150 mg\/day contributes to the reduction of systolic and diastolic blood pressure in individuals with metabolic disorders [2.2].<\/li>\n<\/ul>\n<h4>Metabolic Regulation<\/h4>\n<ul>\n<li><b>Glycemic Control:<\/b> It is established that *trans*-Resveratrol at doses higher than 100 mg\/day may have a <b>hypoglycemic effect<\/b> [1.5, 3.4]. This is associated with its ability to increase insulin sensitivity and protect pancreatic beta-cells [3.2].<\/li>\n<li><b>Lipid Profile:<\/b> Clinical studies have noted that Resveratrol intake contributes to lowering LDL cholesterol levels (the so-called &#8220;bad&#8221; cholesterol) [2.2, 3.4].<\/li>\n<\/ul>\n<hr \/>\n<p>&nbsp;<\/p>\n<h3>Advantages of the MST\u00ae Formula and 150 mg Dosage<\/h3>\n<p>MST\u00ae Resveratrol is a high-purity product that ensures precise dosing of the active ingredient.<\/p>\n<ul>\n<li><b>Critical Dosage:<\/b> Each capsule contains <b>150 mg of *trans*-Resveratrol<\/b>. This is the dose that, in clinical studies, has been identified as the threshold for demonstrating significant effects on vascular function and metabolic markers [2.2].<\/li>\n<li><b>Purity of Form:<\/b> The use of Japanese Knotweed root extract guarantees a high concentration of the <b>trans-isomer<\/b>, which is key for SIRT1 activation and providing antioxidant protection [1.7].<\/li>\n<li><b>German Quality (MADE IN GERMANY):<\/b> Manufacturing in Germany ensures compliance with strict European standards of quality and purity.<\/li>\n<\/ul>\n<hr \/>\n<p>&nbsp;<\/p>\n<h2>Detailed Review of Ingredients and Dosage (per 1 capsule \u2013 daily serving)<\/h2>\n<p>&nbsp;<\/p>\n<p>The MST\u00ae Resveratrol formula contains minimal auxiliary components, focusing on the purity of the active substance.<\/p>\n<table>\n<thead>\n<tr>\n<td><strong>\u0406\u043d\u0433\u0440\u0435\u0434\u0456\u0454\u043d\u0442 (Zutaten) \/ Ingredient<\/strong><\/td>\n<td><strong>1 \u041a\u0430\u043f\u0441\u0443\u043b\u0430 (1 Capsule)<\/strong><\/td>\n<td><strong>\u0424\u0443\u043d\u043a\u0446\u0456\u044f \u0406\u043d\u0433\u0440\u0435\u0434\u0456\u0454\u043d\u0442\u0430 \/ Ingredient Function<\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u0415\u043a\u0441\u0442\u0440\u0430\u043a\u0442 \u043a\u043e\u0440\u0435\u043d\u044f \u042f\u043f\u043e\u043d\u0441\u044c\u043a\u043e\u0433\u043e \u0433\u043e\u0440\u0446\u044f (*Japanese knotweed root extract*)<\/td>\n<td>153 mg<\/td>\n<td>Source of *trans*-Resveratrol<\/td>\n<\/tr>\n<tr>\n<td>&#8211; \u0437 \u043d\u0438\u0445 *\u0442\u0440\u0430\u043d\u0441*-\u0420\u0435\u0441\u0432\u0435\u0440\u0430\u0442\u0440\u043e\u043b (*of which trans-Resveratrol*)<\/td>\n<td><b>150 mg<\/b><\/td>\n<td>Active stilbenoid for cellular regulation and protection<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><b>Other Components:<\/b> Filler (cellulose), Hydroxypropyl Methylcellulose (capsule shell), magnesium salts of fatty acids, silicon dioxide (anti-caking agents). The product may contain traces of soy and milk.<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h2>Recommendations for Taking MST\u00ae Resveratrol<\/h2>\n<p>To achieve maximum effectiveness and adhere to research protocols, it is important to follow the recommended intake regimen.<\/p>\n<p><b>Recommended Dosage:<\/b><\/p>\n<ul>\n<li>Take <b>1 capsule<\/b> daily.<\/li>\n<\/ul>\n<p><b>Intake Schedule:<\/b><\/p>\n<ul>\n<li>The capsule should be taken <b>daily<\/b>, with plenty of water.<\/li>\n<\/ul>\n<p><b>Important Warnings:<\/b><\/p>\n<ol start=\"1\">\n<li><b>Do not exceed<\/b> the recommended daily dose.<\/li>\n<li>The product is a food supplement and cannot replace a complete, balanced diet.<\/li>\n<li><b>Consultation with a specialist:<\/b> Individuals taking any medications, especially anticoagulants or blood pressure regulating drugs, as well as pregnant or nursing women, should consult a specialist before use.<\/li>\n<li><b>Storage:<\/b> Store in a dry, cool place, out of reach of small children.<\/li>\n<\/ol>\n<hr \/>\n<h2>Where to Buy MST\u00ae RESVERATROL: Availability and Quality Guarantee<\/h2>\n<h3>Buy in Ukraine: Delivery to Major Cities<\/h3>\n<p>The original <b>MST\u00ae Resveratrol 60 capsules<\/b>, guaranteed German quality, is available for order throughout Ukraine. We ensure fast delivery to <b>official points of sale<\/b>, <b>leading online stores<\/b> of specialized nutrition, and directly to your city.<\/p>\n<p>Looking for where to <b>buy Resveratrol<\/b> of high purity? Choose verified sources to get <b>150 mg of *trans*-Resveratrol<\/b> at the <b>best price<\/b>.<\/p>\n<p>Main delivery and sales cities:<\/p>\n<ul>\n<li><b>Kyiv, Kharkiv, Odesa, Dnipro, Lviv<\/b>: Fast courier delivery and availability in partner networks.<\/li>\n<li><b>Zaporizhzhia, Kryvyi Rih, Mykolaiv, Vinnytsia, Kherson<\/b>: Prompt dispatch via logistics companies.<\/li>\n<li><b>All other settlements<\/b>: Delivery by your preferred postal operator.<\/li>\n<\/ul>\n<p>Ensure the product&#8217;s <b>100% originality<\/b>. Order now to begin supporting your cellular functions!<\/p>\n<ul>\n<li><b>Ukrainian Official Website:<\/b> <a href=\"https:\/\/mstnutrition.ua\/product\/mst-resveratrol-60-caps\/\">MST\u00ae Resveratrol 60 capsules \u2014 Order here<\/a><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Buy in the EU (European Union): MADE IN GERMANY<\/h3>\n<p>The product <b>MST\u00ae Resveratrol<\/b>, manufactured in Germany, is widely available through the MST Nutrition distribution network in Europe. Secure <b>premium quality<\/b> and <b>European delivery standards<\/b>.<\/p>\n<p>We cover all major EU markets:<\/p>\n<ul>\n<li><b>Germany (Germany)<\/b>: Berlin, Munich, Hamburg.<\/li>\n<li><b>Poland (Poland)<\/b>: Warsaw, Krakow.<\/li>\n<li><b>France (France)<\/b>: Paris, Marseille.<\/li>\n<li><b>Italy (Italy)<\/b>: Rome, Milan.<\/li>\n<li><b>Spain (Spain)<\/b>: Madrid, Barcelona.<\/li>\n<\/ul>\n<p>For ordering in the EU, please visit the official German manufacturer&#8217;s website:<\/p>\n<ul>\n<li><b>German Official Website:<\/b> <a href=\"https:\/\/mst-nutrition.de\/products\/resveratrol-60-kapseln?_pos=1&#038;_psq=Res&#038;_ss=e&#038;_v=1.0\">Resveratrol 60 Kapseln \u2014 Premium Quality<\/a><\/li>\n<\/ul>\n<h2>Research Sources<\/h2>\n<p>[1.1] Resveratrol-like Compounds as SIRT1 Activators. ResearchGate, 2025. (Mechanism and SIRT1 activation).<\/p>\n<p>[1.2] The role of sirtuin 1 and its activator, resveratrol in osteoarthritis. PMC, 2019. (SIRT1, longevity, and *Polygonum cuspidatum* source).<\/p>\n<p>[1.3] Mechanism of Human SIRT1 Activation by Resveratrol. ResearchGate, 2005. (SIRT1 activation dependency).<\/p>\n<p>[1.4] Resveratrol and SIRT1 Activators for the Treatment of Aging and Age-Related Diseases. ResearchGate, 2019. (Source and pleiotropic effects).<\/p>\n<p>[1.5] Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes. NIH, 2023. (Dose-dependent effects on SIRT1, metabolism, and oxidative stress).<\/p>\n<p>[1.7] Resveratrol-like Compounds as SIRT1 Activators. MDPI, 2022. (SIRT1, vascular oxidative stress, antioxidant genes).<\/p>\n<p>[2.2] Effect of Resveratrol on the Cardiovascular System. Encyclopedia.pub, 2021. (Blood pressure and lipid profile reduction at doses > 150 mg\/day).<\/p>\n<p>[2.3] Resveratrol and Cardiovascular Diseases. PMC, 2015. (*trans*-form, NO bioavailability, cardioprotection).<\/p>\n<p>[3.1] Bulk Polygonum Cuspidatum Extract (Trans-Resveratrol >20%). Ingredients Online. (Source description and purity).<\/p>\n<p>[3.2] Polygonum cuspidatum \u2013 Knowledge and References. Taylor &#038; Francis. (Traditional use and metabolic\/circulatory protective effects).<\/p>\n<p>[3.3] Trans Resveratrol &#8211; Polygonum Cuspidatum. Hydra Longevity. (Metabolic performance and blood flow improvement).<\/p>\n<p>[3.4] A Comparative Evaluation of the Antioxidant Ability of Polygonum cuspidatum Extracts with That of Resveratrol Itself. MDPI, 2023. (Source, purity, and metabolic effects).<\/p>\n<p>[3.7] Polygonum Cuspidatum Extract 98% Trans Resveratrol. Phytochem International Inc. (Source purity confirmation).<\/p>\n<p style=\"text-align: center\"><img decoding=\"async\" class=\"alignnone size-medium wp-image-1001991 lazyload\" data-src=\"https:\/\/mstnutrition.ua\/wp-content\/uploads\/2025\/11\/1-2-500x500.png\" alt=\"Square photo of MST\u00ae Resveratrol 150 mg surrounded by green Japanese knotweed leaves and root fragments, emphasizing natural origin and cellular vitality.\" width=\"500\" height=\"500\" data-srcset=\"https:\/\/mstnutrition.ua\/wp-content\/uploads\/2025\/11\/1-2-500x500.png 500w, https:\/\/mstnutrition.ua\/wp-content\/uploads\/2025\/11\/1-2-1024x1024.png 1024w, https:\/\/mstnutrition.ua\/wp-content\/uploads\/2025\/11\/1-2-150x150.png 150w, https:\/\/mstnutrition.ua\/wp-content\/uploads\/2025\/11\/1-2-768x768.png 768w, https:\/\/mstnutrition.ua\/wp-content\/uploads\/2025\/11\/1-2-88x88.png 88w, https:\/\/mstnutrition.ua\/wp-content\/uploads\/2025\/11\/1-2-490x490.png 490w, https:\/\/mstnutrition.ua\/wp-content\/uploads\/2025\/11\/1-2-360x360.png 360w, https:\/\/mstnutrition.ua\/wp-content\/uploads\/2025\/11\/1-2-250x250.png 250w, https:\/\/mstnutrition.ua\/wp-content\/uploads\/2025\/11\/1-2-300x300.png 300w, https:\/\/mstnutrition.ua\/wp-content\/uploads\/2025\/11\/1-2-600x600.png 600w, https:\/\/mstnutrition.ua\/wp-content\/uploads\/2025\/11\/1-2-100x100.png 100w, https:\/\/mstnutrition.ua\/wp-content\/uploads\/2025\/11\/1-2-64x64.png 64w, https:\/\/mstnutrition.ua\/wp-content\/uploads\/2025\/11\/1-2-154x154.png 154w, https:\/\/mstnutrition.ua\/wp-content\/uploads\/2025\/11\/1-2.png 1080w\" data-sizes=\"(max-width: 500px) 100vw, 500px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 500px; --smush-placeholder-aspect-ratio: 500\/500;\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>MST\u00ae RESVERATROL: Support for Cellular Metabolism and Regulation of Aging Pathways &nbsp; MST\u00ae Resveratrol 60 capsules is a high-quality German-made<\/p>\n<div class=\"readmore\"><a class=\"btn btn-red-white\" href=\"https:\/\/mstnutrition.ua\/en\/resveratrol-dovgolittya-ta-sirt1\/\">Read more<\/a><\/div>\n","protected":false},"author":1541,"featured_media":1001992,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[38,332],"tags":[],"class_list":["post-1001985","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","category-additives"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Resveratrol: Longevity and SIRT1<\/title>\n<meta name=\"description\" content=\"Resveratrol from Japanese Highlander. 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Supports metabolism, blood vessels and longevity functions SIRT1. 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Supports metabolism, blood vessels and longevity functions SIRT1. Buy German quality.[:]","og_url":"https:\/\/mstnutrition.ua\/en\/resveratrol-dovgolittya-ta-sirt1\/","og_site_name":"MST Nutrition UA","article_published_time":"2025-11-17T19:17:23+00:00","article_modified_time":"2025-11-17T20:17:16+00:00","og_image":[{"width":1080,"height":1080,"url":"https:\/\/mstnutrition.ua\/wp-content\/uploads\/2025\/11\/2-2.png","type":"image\/png"}],"author":"Mykola300","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/mstnutrition.ua\/ru\/resveratrol-dovgolittya-ta-sirt1\/#article","isPartOf":{"@id":"https:\/\/mstnutrition.ua\/ru\/resveratrol-dovgolittya-ta-sirt1\/"},"author":{"name":"Mykola300","@id":"https:\/\/mstnutrition.ua\/#\/schema\/person\/42eb1bdd0df41bc92f77d98093d0caf6"},"headline":"Resveratrol: Longevity and SIRT1","datePublished":"2025-11-17T19:17:23+00:00","dateModified":"2025-11-17T20:17:16+00:00","mainEntityOfPage":{"@id":"https:\/\/mstnutrition.ua\/ru\/resveratrol-dovgolittya-ta-sirt1\/"},"wordCount":3718,"commentCount":0,"image":{"@id":"https:\/\/mstnutrition.ua\/ru\/resveratrol-dovgolittya-ta-sirt1\/#primaryimage"},"thumbnailUrl":"https:\/\/mstnutrition.ua\/wp-content\/uploads\/2025\/11\/2-2.png","articleSection":["Blog","Additives"],"inLanguage":"en-GB","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/mstnutrition.ua\/ru\/resveratrol-dovgolittya-ta-sirt1\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/mstnutrition.ua\/ru\/resveratrol-dovgolittya-ta-sirt1\/","url":"https:\/\/mstnutrition.ua\/ru\/resveratrol-dovgolittya-ta-sirt1\/","name":"Resveratrol: Longevity and SIRT1","isPartOf":{"@id":"https:\/\/mstnutrition.ua\/#website"},"primaryImageOfPage":{"@id":"https:\/\/mstnutrition.ua\/ru\/resveratrol-dovgolittya-ta-sirt1\/#primaryimage"},"image":{"@id":"https:\/\/mstnutrition.ua\/ru\/resveratrol-dovgolittya-ta-sirt1\/#primaryimage"},"thumbnailUrl":"https:\/\/mstnutrition.ua\/wp-content\/uploads\/2025\/11\/2-2.png","datePublished":"2025-11-17T19:17:23+00:00","dateModified":"2025-11-17T20:17:16+00:00","author":{"@id":"https:\/\/mstnutrition.ua\/#\/schema\/person\/42eb1bdd0df41bc92f77d98093d0caf6"},"description":"Resveratrol from Japanese Highlander. 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